STAT5b inhibitor 7 ( Capstafin prodrug )

Catalog No. M12797 CAS No. 1818390-58-7

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Product Name

STAT5b inhibitor 7
Note

Research use only, not for human use.
Brief Description

STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin.
Description

STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin, which is a potent, selective STAT5b inhibitor with Ki of 0.34 uM; inhibits STAT5b with selectivity over STAT5a in human tumor cells, inhibits cell viability and induces apoptosis in human tumor cells in a STAT5-dependent manner.
Synonyms

Capstafin prodrug
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

CAS Number

1818390-58-7
Formula Weight

909.94
Molecular Formula

C41H69NO17P2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)CCCCCCC(NCC1=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)=C1)=O
Chemical Name

((((4-((8-methylnonanamido)methyl)-1,2-phenylene)bis(oxy))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene) tetrakis(2,2-dimethylpropanoate)

1. Elumalai N, et al. ACS Chem Biol. 2015 Dec 18;10(12):2884-90.

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